期刊
NEUROIMAGE-CLINICAL
卷 25, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2020.102169
关键词
Resting State fMRI; Modularity; Dynamic functional connectivity; Multilayer community detection; Flexibility; Network switching; Schizophrenia; Module allegiance; Transition matrix
类别
资金
- National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Heath Research and Care South London at King's College Hospital NHS Foundation Trust
- National Institute of Health Centre of Biomedical Research Excellence (COBRE) [1P20RR021938-01A2]
- Mind Research Network
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- Comision Nacional de Investigacion Cientifica y Tecnologica: CONICYT FONDECYT [1160736]
- CONICYT [PIA ACT192064]
- Cambridge Philosophical Society
- MRC [MC_PC_11003] Funding Source: UKRI
Novel methods for measuring large-scale dynamic brain organisation are needed to provide new biomarkers of schizophrenia. Using a method for modelling dynamic modular organisation (Mucha et al., 2010), evidence suggests higher 'flexibility' (switching between multilayer network communities) to be a feature of schizophrenia (Braun et al., 2016). The current study compared flexibility between 55 patients with schizophrenia and 72 controls (the COBRE Dataset). In addition, novel methods of 'between resting state network synchronisation' (BRSNS) and the probability of transition from one community to another were used to further describe group differences in dynamic community structure. There was significantly higher schizophrenia group flexibility scores in cerebellar (F (1124) = 9.33, p (FDR) = 0.017), subcortical (F (1124) = 13.14, p (FDR) = 0.005), and fronto-parietal task control (F (1124) = 7.19, p (FDR) = 0.033) resting state networks (RSNs), as well as in the left thalamus (MNI XYZ: -2, -13, 12; F(1, 124) = 17.1, p (FDR) < 0.001) and the right crus I (MNI XYZ: 35, -67, -34; F (1, 124) = 19.65, p (FDR) < 0.001). Flexibility in the left thalamus reflected transitions between communities covering default mode and sensory-somatomotor RSNs. BRSNS scores suggested altered dynamic interRSN modular configuration in schizophrenia. This study suggests less stable community structure in a schizophrenia group at an RSN and node level and provides novel methods of exploring dynamic community structure. Mediation of group differences by mean time window correlation did however suggest flexibility to be no better as a schizophrenia biomarker than simpler measures and a range of methodological choices affected results.
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