期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 22, 期 8, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.22.8.086013
关键词
Brillouin microscopy; optical coherence tomography; embryonic imaging; tissue mechanics
资金
- National Institute of Health [R01HL120140, R01HD086765]
Embryogenesis is regulated by numerous changes in mechanical properties of the cellular micro-environment. Thus, studying embryonic mechanophysiology can provide a more thorough perspective of embryonic development, potentially improving early detection of congenital abnormalities as well as evaluating and developing therapeutic interventions. A number of methods and techniques have been used to study cellular biomechanical properties during embryogenesis. While some of these techniques are invasive or involve the use of external agents, others are compromised in terms of spatial and temporal resolutions. We propose the use of Brillouin microscopy in combination with optical coherence tomography (OCT) to measure stiffness as well as structural changes in a developing embryo. While Brillouin microscopy assesses the changes in stiffness among different organs of the embryo, OCT provides the necessary structural guidance. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
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