期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 106, 期 5, 页码 2065-2071出版社
WILEY
DOI: 10.1002/jbm.b.33953
关键词
epigenetics; tissue engineering; surface topography; material energy; titanium; regenerative medicine
资金
- NIH/NIDCR [DE13397]
- Royal Swedish Academy of Sciences Stiftelsen PE Lindahls stipendiefond
- National Institute of Dental and Craniofacial Research [DE13397]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE013397, T32DE007057] Funding Source: NIH RePORTER
The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2065-2071, 2018.
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