期刊
GREEN CHEMISTRY
卷 22, 期 5, 页码 1565-1571出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9gc03496j
关键词
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资金
- National Research Foundation (NRF) of Korea - Korean Government [NRF-2017R1A3B1023598]
- CSIR-IICT [IICT/Pubs./2019/445]
Visible-light-driven continuous-flow decarboxylative annulation was achieved and used along with a microreactor containing immobilized ruthenium catalyst to construct valuable fused imidazole derivatives with high yields under an open atmosphere. Notably, this chemistry included the use of l-proline and alpha-azidochalcone as precursors of an alpha-amino radical and 2H-azirine via photo-induced decarboxylation and denitrogenation, respectively, to give the annulated imidazole derivatives as a result of the formation of two new C-N bonds. Moreover the novel, environmentally benign and efficient continuous-flow protocol was further improved by carrying out the reaction in a polydimethylsiloxane (PDMS) microreactor with immobilized Ru3+ under fluorescent or white LED light, enabling excellent yields (70-94%) at a reaction time (2 min) significantly shorter than that (16 h) of the batch protocol.
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