期刊
DALTON TRANSACTIONS
卷 44, 期 34, 页码 15145-15156出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt03585b
关键词
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资金
- 973 program [2014CB845604, 2015CB856301]
- National Science Foundation of China [21172273, 21171177, 21471164]
- Program for Changjiang Scholars and Innovative Research Team in University of China [IRT1298]
- Research Fund for the Doctoral Program of Higher Education [20110171110013]
One novel ruthenium polypyridyl complex, [Ru(bpy)(2)(icip)](2+) (1), and two previously reported ruthenium polypyridyl complexes, [Ru(bpy)(2)(pdppz)](2+) (2) and [Ru(bpy)(2)(tactp)](2+) (3) (bpy = 2,2'-bipyridine, icip = 2-(indeno[2,1-b] chromen-6-yl)-1H-imidazo[4,5-f][1,10] phenanthroline, pdppz = phenanthro[4,5-abc] dipyrido[ 3,2-h:2', 3'-j] phenazine, tactp = 4,5,9,18-tetraazachryseno[9,10-b]-triphenylene), have been synthesised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure, and behave as topoisomerase I/II poisons at the same time. Additionally, the acute and chronic cytotoxicities of the complexes are considered. Furthermore, cell apoptosis experiments are used to briefly study the mechanism. Because studies involving multi-target inhibition towards topoisomerase and telomerase of Ru(II) complexes have not been reported previously, the present research may help to develop innovative chemical strategies and therapies.
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