期刊
AGING AND DISEASE
卷 11, 期 2, 页码 390-404出版社
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2019.0519
关键词
blood brain barrier; ATP binding cassette transporters; solute carrier; Alzheimer's disease
资金
- National Natural Science Foundation of China [81803869, 81303248]
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2016116, UNPYSCT-2018032]
- Science and Technology Research Project of the Education Department of Heilongjiang Province [2017-KYYWF0697]
- Item of Scientific Research Fund For Doctors of Qiqihar Medical University [QMSI2017B-10]
The neurovascular unit (NVU) plays an important role in maintaining the function of the central nervous system (CNS). Emerging evidence has indicated that the NVU changes function and molecules at the early stage of Alzheimer's disease (AD), which initiates multiple pathways of neurodegeneration. Cell types in the NVU have become attractive targets in the interventional treatment of AD. The NVU transportation system contains a variety of proteins involved in compound transport and neurotransmission. Brain transporters can be classified as members of the solute carrier (SLC) and ATP-binding cassette (ABC) families in the NVU. Moreover, the transporters can regulate both endogenous toxins, including amyloid-beta (AD) and xenobiotic homeostasis, in the brains of AD patients. Genome-wide association studies (GWAS) have identified some transporter gene variants as susceptibility loci for late-onset AD. Therefore, the present study summarizes changes in blood-brain barrier (BBB) permeability in AD, identifies the location of SLC and ABC transporters in the brain and focuses on major SLC and ABC transporters that contribute to AD pathology.
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