期刊
JOURNAL OF BIOMECHANICS
卷 50, 期 -, 页码 20-25出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2016.11.016
关键词
Mechanotransduction; Platelet activation; Mechanical circulatory support; Thrombosis; Fluid shear stress
资金
- National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health [5U01EB012487-05]
Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for free flow activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety. (C) 2016 Elsevier Ltd. All rights reserved.
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