期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 28, 期 14, 页码 1497-1510出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2017.1332470
关键词
PEG-PCL; nanoparticles; Ginkgolide B; in vitro release
资金
- Key Research Projects of University in Henan province [15A350012, 17A350001]
- Scientific & Technological Projects of Henan province [172102310616]
- Scientific Research Fund of Xinxiang Medical University [2013ZD119]
- High educated talents fund of Xinxiang Medical University, China [100778]
The amphiphilic PEG-b-PCL block copolymers were synthesized by ring-opening polymerization. The specific and selective antagonists of platelet activating factor, Ginkgolide B (GB), was successfully encapsulated in the synthesized PEG-PCL nanoparticles (NPs) with high Encapsulation Efficiency and Drug Loading. The synthesis of different PEG-PCL copolymers were confirmed with FTIR and H-1 NMR spectra. The morphology and particles size distribution of cargo-free PEG-PCL NPs were studied by transmission electron microscope (TEM) analysis and Malvern laser particle analyzer. The bio-distribution and pharmacodynamics studies of GB were studied with Wistar mice as the animal models via tail injecting of GB-PEG-PCL NPs. Results from Malvern laser particle analyzer and TEM analysis illustrated that the cargo-free NPs showed narrow distribution and well separated particles size of about 60 nm in diameter. The in vitro experiment of GB-PEG-PCL NPs exhibited an extended release behavior. The bio-distribution data suggested that Tween-80 covered GB-PEG-PCL NPs showed a brain-targeting behavior. The pharmacodynamics results confirmed that the GB-PEG-PCL NPs had an obvious cerebral protection effect.
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