期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 31, 期 10, 页码 1380-1390出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328217702526
关键词
Gelatin; hyaluronic acid; hydrogel; moist environment; wound healing
资金
- National Science Foundation of China [81301636]
Excellent wound dressings maintain a warm and moist environment, thus accelerating wound healing. In this study, we cross-linked gelatin and hyaluronic acid with ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride in different ratios (gelatin/hyaluronic acid=8:2, gelatin/hyaluronic acid=5:5, gelatin/hyaluronic acid=2:8), and explored the effects and mechanisms of gelatinhyaluronic acid hydrogels on wound healing. This was done by examining dressing properties, such as fluid uptake ability, water vapor transmission rate, and the rate of water evaporation. We further verified biological function by using invitro and invivo wound models. The hydrogels display appropriate fluid uptake ability and good water vapor transmission rate and rate of water evaporation all of which can provide an adequate moisture environment for wound healing. Cell cytotoxicity and proliferation tests show that the hydrogels have no cytotoxicity, furthermore, gelatin/hyaluronic acid=8:2 hydrogels have the potential to promote cell proliferation. Animal wound models demonstrate that the hydrogels can effectively promote wound healing invivo, in particular, the gelatin/hyaluronic acid=8:2 group which promoted the most rapid healing. Accordingly, gelatin-hyaluronic acid dressings, especially the gelatin/hyaluronic acid=8:2 hydrogels, have a promising outlook for clinical applications in wound healing.
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