期刊
JOURNAL OF BIOMEDICAL SCIENCE
卷 27, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12929-020-00640-3
关键词
Long non-coding RNA; RNA-interactome; Epigenetics; Chromatin; Nuclear architecture; R-loops; Phase separation
资金
- Ministry of Science and Technology (MOST) [106-2311-B-002-039-MY2, 108-2628-B-002-004]
- National Taiwan University [NTU-CDP-108 L7732, NTU-AS-108 L104305, NTU-CC-107 L892003]
Protein and DNA have been considered as the major components of chromatin. But beyond that, an increasing number of studies show that RNA occupies a large amount of chromatin and acts as a regulator of nuclear architecture. A significant fraction of long non-coding RNAs (lncRNAs) prefers to stay in the nucleus and cooperate with protein complexes to modulate epigenetic regulation, phase separation, compartment formation, and nuclear organization. An RNA strand also can invade into double-stranded DNA to form RNA:DNA hybrids (R-loops) in living cells, contributing to the regulation of gene expression and genomic instability. In this review, we discuss how nuclear lncRNAs orchestrate cellular processes through their interactions with proteins and DNA and summarize the recent genome-wide techniques to study the functions of lncRNAs by revealing their interactomes in vivo.
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