期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 31, 页码 12744-12753出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.789537
关键词
energy metabolism; iron-response element (IRE); iron-sulfur protein; metalloenzyme; mitochondrial respiratory chain complex; HSC20; HSPA9; ISCU; iron-sulfur cluster biogenesis
资金
- Eunice Kennedy Shriver NICHD Intramural Research Program
Fe-S cofactors are composed of iron and inorganic sulfur in various stoichiometries. A complex assembly pathway conducts their initial synthesis and subsequent binding to recipient proteins. In this minireview, we discuss how discovery of the role of the mammalian cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characterization of the function of its Fe-S cluster in sensing and regulating cellular iron homeostasis. Moreover, we present an overview of recent studies that have provided insights into the mechanism of Fe-S cluster transfer to recipient Fe-S proteins.
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