期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 9, 页码 3720-3728出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M116.763813
关键词
Alzheimer disease; inflammation; microglia; neuroinflammation; phagocytosis
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Scientific Research on Innovation Area (Brain Protein Aging and Dementia control)
- Japan Agency for Medical Research and Development (AMED) DEMENTIA Research and Development Project [16dk0207026h0301]
- Grants-in-Aid for Scientific Research [26117004] Funding Source: KAKEN
Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long, healthy life. Here we found that iso--acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor . In normal mice, oral administration of iso--acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain. In Alzheimer's model 5xFAD mice, oral administration of iso--acids resulted in a 21% reduction in amyloid in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1 and chemokines including macrophage inflammatory protein-1 in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice. The differences in iso--acid-fed mice were due to the induction of microglia to an anti-inflammatory phenotype. The present study is the first to report that amyloid deposition and inflammation are suppressed in a mouse model of Alzheimer's disease by a single component, iso--acids, via the regulation of microglial activation. The suppression of neuroinflammation and improvement in cognitive function suggests that iso--acids contained in beer may be useful for the prevention of dementia.
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