期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 28, 页码 11601-11609出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.776054
关键词
cancer; isotopic tracer; mass spectrometry (MS); metabolism; metabolomics; nuclear magnetic resonance (NMR)
资金
- National Institutes of Health [T32CA165990, 1R01ES022191-01, 1P01CA163223-01A1]
Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.
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