期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 293, 期 15, 页码 5404-5413出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.TM117.000117
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资金
- Deutsche Forschungsgemeinschaft [SFB 1177]
- European Research Council (ERC) Grant Ub-BAC
- Cluster of Excellence Macromolecular Complexes Grant [EXC 115]
- LOEWE Grant Ub-Net
- LOEWE Centre for Gene and Cell Therapy Frankfurt (CGT)
- COFUND, Goethe International Postdoc Programme (GO-IN) Grant [291776]
Ubiquitination is a widespread post-translational modification that controls multiple steps in autophagy, a major lyso-some-mediated intracellular degradation pathway. A variety of ubiquitin chains are attached as selective labels on protein aggregates and dysfunctional organelles, thus promoting their autophagy-dependent degradation. Moreover, ubiquitin modification of autophagy regulatory components is essential to positively or negatively regulate autophagy flux in both non-selective and selective pathways. We review the current findings that elucidate the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of amplitude and selectivity of autophagy pathways as well as their impact on the development of human diseases.
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