期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 49, 页码 19987-19988出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.H117.801936
关键词
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资金
- National Institutes of Health [R01 DK062388]
- American Diabetes Association [DA 7-13-BS-540 118]
- U.S. Department of Agriculture Hatch grants [W2005]
9-Desaturases are central enzymes in unsaturated fatty acid synthesis regulated at the transcriptional and mRNA levels and by proteasomal degradation. A new study by Murakami et al. uncovers a novel regulatory pathway in which an N-terminal di-proline motif in the Drosophila 9-desaturase mediates protein degradation by a calcium-dependent cysteine protease in response to unsaturated fatty acids. This study provides new details of desaturase regulation with therapeutic implications for the treatment of metabolic syndrome.
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