期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 23, 页码 9441-9450出版社
ELSEVIER
DOI: 10.1074/jbc.R117.787713
关键词
-
资金
- National Institutes of Health from NIGMS [GM063162]
Divalent ions fulfill essential cellular roles and are required for virulence by certain bacteria. Free intracellular Mg2+ can approach 5 mM, but at this level Mn2+, Ni2+, or Co2+ can be growth-inhibitory, and magnesium fluoride is toxic. To maintain ion homeostasis, many bacteria have evolved ion sensors embedded in the 5 '- leader sequences of mRNAs encoding ion uptake or efflux channels. Here, we review current insights into these metalloriboswitches, emphasizing ion-specific binding by structured RNA aptamers and associated conformational changes in downstream signal sequences. This riboswitch-effector interplay produces a layer of gene regulatory feedback that has elicited interest as an antibacterial target.
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