期刊
RSC ADVANCES
卷 10, 期 14, 页码 8104-8114出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra10447j
关键词
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资金
- National Research Foundation (NRF)
- Medical Research Council (MRC) of South Africa
- University of the Witwatersrand through the School of Chemistry and Research Office
Novel tetracyclic imidazo[1,2-a]pyridine derivatives have been prepared by intramolecular nucleophilic aromatic substitution of 5-fluoroimidazo[1,2-a]pyridines under basic conditions. Use of the non-nucleophilic alcoholic solvent tert-butanol, rather than methanol, increased the yield of the tetracycles by reducing the competing intermolecular reaction observed for methanol. In addition, a modified protocol for the dehydration of formamides to isocyanides has been found to be tolerant of an unprotected hydroxyl functional group and one-pot conversion to imidazo[1,2-a]pyridyl-aminocyclohexanol analogues is reported.
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