期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 44, 页码 17981-17990出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.802512
关键词
ABC transporter; gram-negative bacteria; lipopolysaccharide (LPS); outer membrane; protein-protein interaction; LPS transport
资金
- Train2Target project from the European Union [721484]
The outer membrane (OM) of Gram-negative is a unique lipid bilayer containing LPS in its outer leaflet. Because of the presence of amphipathic LPS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria inherently resistant to many antibiotics. This review focuses on LPS biogenesis and discusses recent advances that have contributed to our understanding of how this complex molecule is transported across the cellular envelope and is assembled at the OM outer leaflet. Clearly, this knowledge represents an important platform for the development of novel therapeutic options to manage Gram-negative infections.
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