期刊
JOURNAL OF AUTOIMMUNITY
卷 84, 期 -, 页码 21-28出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2017.09.001
关键词
Small ubiquitin-like modifier (SUMO) proteins; Innate immune system; NF-kappa B pathway; Interferon pathway; Autoimmunity
类别
资金
- Vietnam Ministry of Science and Technology (MOST)
- Italian Ministero degli Esteri e della Cooperazione Internazionale (MAECI)
- Associazione Italiana per la ricerca contro il cancro (AIRC)
Small ubiquitin-like modifier (SUMO) proteins belong to the ubiquitin-like family and act to change the function of target proteins through post-translational modifications. Through their interactions with innate immune pathways, SUMOs promote an efficient immune response to pathogenic challenge avoiding, at the same time, an excess of immune response that could lead to the development of autoimmune diseases. This report discusses the general functions of SUMO proteins; highlights SUMO involvement in the innate immune response through their role in NF-kappa B and interferon pathways; the involvement of SUMO proteins in auto immune diseases; and reviews bacterial, viral, and parasitic interactions with SUMO pathways. In conclusion, we speculate that targeting SUMOs could represent a new therapeutic strategy against infections and autoimmunity. (C) 2017 Elsevier Ltd. All rights reserved.
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