期刊
TOXICOLOGICAL RESEARCH
卷 36, 期 4, 页码 329-336出版社
KOREAN SOC TOXICOLOGY
DOI: 10.1007/s43188-020-00041-6
关键词
Dermatitis; Cytokines; Cosmetics; Infammation; Immunity; Risk
类别
资金
- Ministry of Food and Drug Safety, Korea [18172MFDS231, 19172MFDS221]
Due to high consumption of cosmetics in modern society, people are always exposed to the risk of skin damage and complications. Para-phenylenediamine (P-PD), an ingredient of hair dye, has been reported to cause allergic contact dermatitis. However, the mechanism has not been well elucidated. Here, we identify that P-PD causes dermatitis by increasing thymic stromal lymphopoietin (TSLP) and inflammatory cytokines. Topical application of P-PD to mouse ear skin in consecutive 5 days resulted in dermatitis symptoms and increased ear thickness. TSLP production in skin was upregulated by P-PD treatment alone. In addition, P-PD-induced TSLP production was potentiated by MC903, which is an in vivo TSLP inducer. P-PD increased TSLP production in keratinocytes (KCMH-1 cells and phorbol 12-myristate 13-acetate-stimulated PAM212 cells). The production of proinflammatory cytokines such as IL-1 beta, IL-6, IFN-gamma, and CCL2, was upregulated by P-PD treatment together with MC903. The results show that repeated exposure to P-PD causes acute contact dermatitis mediated by increasing the expression of TSLP and proinflammatory cytokines.
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