期刊
DATA IN BRIEF
卷 28, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.dib.2019.105029
关键词
Mouse macrophage cell line; TBEV; Proteomics; Protein; Mass spectrometry; Label-free quantification
资金
- Ministry of Science and Higher Education of the Russian Federation [14.616.21.0094, RFMEFI61618X0094]
- Ministry of Education, Youth and Sports of the Czech Republic [LTARF 18021]
We report the proteomic datasets on the mouse macrophage cell line PMJ2R infected with tick-borne encephalitis virus (TBEV) for two and six days. Data were acquired using shotgun ultra-high resolution mass spectrometry. Peptide identifications were done using the Mascot version 2.4 (Matrix Science), and quantification was performed by a label-free approach. Protein profiles of early (two days) and late (six days) stages of infection were compared between each other and the respective control samples. Protein profiles of infected and control samples differed in the number of identified proteins and their relative abundances. Proteins detected in the TBEV-infected cells were involved in various processes related to the infection, including defense response against the virus, regulation of viral process, negative regulation of viral genome replication, RNA binding, or innate immune response. Also, proteins specific for the early and late stages of infection were identified. (C) 2019 The Author(s). Published by Elsevier Inc.
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