期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 34, 期 6, 页码 723-724出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-017-0907-5
关键词
IVF; Assisted reproductive technologies; Preimplantation genetic screening; Preimplantation genetic diagnosis; Prenatal screening for aneuploidy; Noninvasive prenatal screening
Obstetricians offer prenatal screening for most common chromosomal abnormalities to all pregnant women including those that had in vitro fertilization (IVF) and preimplantation genetic screening/diagnosis (PGS/D). We propose that free fetal DNA in maternal circulation together with the second trimester maternal serum alfa feto protein (MSAFP) and ultrasound imaging is the best prenatal screening test for chromosomal abnormalities and congenital anomalies in IVF-PGD/S patients because risk estimations from all other prenatal screening algorithms for chromosomal abnormalities depend heavily on maternal age which is irrelevant in PGS/D patients.
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