期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 34, 期 12, 页码 1633-1638出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-017-1016-1
关键词
Estradiol; In vitro fertilization; Frozen embryo transfer cycles; Live birth rates
The aim of this study is to evaluate the correlation between serum estradiol (E-2) levels during artificial autologous frozen embryo transfer (FET) cycles and ongoing pregnancy/live birth rates (OP/LB). A historical cohort study was conducted in an academic setting in order to correlate peak and average estradiol levels with ongoing pregnancy/live birth rates for all autologous artificial frozen embryo transfer cycles performed from 1/2011 to 12/2014. Average and peak E-2 levels from 110 autologous artificial FET cycles from 95 patients were analyzed. Average E-2 levels were significantly lower in cycles resulting in OP/LB compared to those that did not (234.1 +/- 16.6 pg/ml vs. 315 +/- 24.8 pg/ml, respectively, p = 0.04). Although peak E-2 levels were not significantly different between cycles resulting in OP/LB compared with those that did not (366.9 +/- 27.7 pg/ml vs. 459.1 +/- 32.3 pg/ml, respectively, p = 0.19), correlation analysis revealed a statistically significant (p = 0.02) downward trend in OP/LB rates with increasing peak E-2 levels. This study suggests that elevated E-2 levels in artificial autologous FET cycles are associated with lower OP/LB rates. Estradiol levels should be monitored during artificial FET cycles.
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