期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 20, 期 12, 页码 1123-1128出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1378646
关键词
Selaginellaceae; Selaginella pulvinata; selaginellin derivative; triarylbenzophenone; phosphodiesterase-4
资金
- National High Technology Research and Development Program of China [2015AA020928]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306047]
- National Natural Science Foundation of China [81402813]
- Fundamental Research Funds for the Central Universities [14YKPY10]
Five selaginellin derivatives (1 and 3-6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1-6 exhibited potent activities with the IC50 values in the range of 1.04-9.35 mu M. [GRAPHICS] .
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