期刊
JOURNAL OF CANCER
卷 11, 期 12, 页码 3519-3535出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.41841
关键词
lysophosphatidic acid; LPAR; structure; physiology and pathology; cancer
类别
资金
- National Natural Science Foundation of China [81873076]
- Shanghai Rising-Star Project [15QA1403500]
- Shanghai Talents development fund Project [2017090]
Lysophosphatidic acid (LPA, 1-acyl-2-hemolytic-sn-glycerol-3-phosphate) extracted from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has many biological functions such as stimulating cell multiplication, cytoskeleton recombination, cell survival, drug-fast, synthesis of DNA and ion transport. Current studies have shown that six G-coupled protein receptors (LPAR1-6) can be activated by LPA. They stimulate a variety of signal transduction pathways through heterotrimeric G-proteins (such as Ga12/13, Gaq/11, Gai/o and GaS). LPA and its receptors play vital roles in cancers, nervous system diseases, cardiovascular diseases, liver diseases, metabolic diseases, etc. In this article, we discussed the structure of LPA receptors and elucidated their functions in various diseases, in order to better understand them and point out new therapeutic schemes for them.
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