4.7 Article

Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines

期刊

DALTON TRANSACTIONS
卷 44, 期 16, 页码 7135-7138

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c5dt00175g

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资金

  1. Ministerio de Economia y Competitividad (MINECO, Spain) [CTQ2011-22723]
  2. Department of Industry of the Basque Country (grant ETORTEK)
  3. Department of Education, Universities and Research of the Basque Country [2012-33]

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The cisplatin prodrug c,c,t-[Pt(NH3)(2)Cl-2(O2CCH2CH2CO2)(2)](2-) (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, also achieved using PEI-coated AuNPs.

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