期刊
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
卷 25, 期 -, 页码 -出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/jrms.JRMS_256_19
关键词
Cardiovascular risk factors; dietary patterns; lipoprotein-associated phospholipase A2
资金
- Research Institute of Endocrine Sciences, Shahid-Beheshti University of Medical Sciences, Islamic Republic of Iran [824]
Background: Pathogenesis of cardiovascular diseases (CVDs) may be indicated by lipoprotein-associated phospholipase A2 (Lp-PLA2), serving as an inflammatory biomarker. However, the general dietary predictors of Lp-PLA2 have not been investigated so far. The aim of the present study is to investigate the relationship between the serum levels of Lp-PLA2 and dietary patterns in adults with cardiovascular risk factors. Materials and Methods: Dietary patterns extracted using factor analysis and serum levels of Lp-PAL2 in 470 adults aged 40-70 years who participated in the 5th phase of the Tehran Lipid and Glucose Study (2011-2014) were determined. Associations between the dietary patterns and serum levels of Lp-PAL2 considering some confounder factors were evaluated. Results: The results showed that Western and semi-Mediterranean dietary patterns had significant effects on changes in Lp-PLA2 levels in univariate analyses. In multivariate analyses, after adjusting for age, sex, total cholesterol, low-density lipoprotein cholesterol, body mass index and physical activity, energy intake, hormone therapy for women, and taking blood lipid-lowering drugs as potential confounders, the Western dietary pattern remained a significant factor influencing the Lp-PLA2 level (beta value: 1.65, 95% confidence interval: 1.12, 1.89; P < 0.05). Moreover, after adjustment for the mentioned confounder factors, the effect of the semi-Mediterranean dietary pattern on Lp-PLA2 disappeared. Conclusion: It can be concluded that the Western dietary pattern is associated with higher Lp-PLA2 levels. We recommend that adults eat less carbonated drinks, fast foods, salty snacks, mayonnaise, and organ meat to counteract increased serum Lp-PLA2 levels, which are directly associated with vascular inflammation and CVDs.
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