期刊
EMERGING MICROBES & INFECTIONS
卷 9, 期 1, 页码 771-774出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2020.1747950
关键词
Bacteriophage; phage therapy; antibiotic resistance; urinary tract infection
资金
- Shanghai Public Health Clinical Center (SIP project: SJTNY)
- Shanghai Municipal Key Clinical Specialty [shslczdzk01102]
- National Natural Science Foundation of China (NSFC) [31870167]
- Shanghai Municipal Health Commission Scientific Research Project [20194Y0061]
- National Science and Technology Major Project [2020ZX09201001]
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail inhibited the emergence of phage resistant mutant in vitro, and the UTI of patient was successfully cured by this combination. Thus, we propose that non-active antibiotic and bacteriophage synergism (NABS) might be an alternative strategy in personalized phage therapy.
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