期刊
EMERGING INFECTIOUS DISEASES
卷 26, 期 4, 页码 711-720出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2604.190717
关键词
-
资金
- Ministry of Science and Technology (MOST), Taiwan [MOST108-2314-B-182-020-MY3]
- Chang Gung Memorial Hospital, Taiwan [CMRPG3F1591-1592, CMRPG3H1411-1412]
- Research Center for Emerging Viral Infections of the Featured Areas Research Center Program - Ministry of Education, Taiwan [MOST-108-3017-F-182-001]
- Research Center for Emerging Viral Infections of the Featured Areas Research Center Program - MOST [MOST-108-3017-F-182-001]
Incidence of invasive pneumococcal disease caused by antimicrobial-resistant Streptococcus pneumoniae types not included in pneumococcal conjugate vaccines has increased, including a penicillin- and meropenem-resistant serotype 15A-ST63 clone in Japan. During 2013-2017, we collected 206 invasive pneumococcal isolates in Taiwan for penicillin and meropenem susceptibility testing. We found serotypes 15B/C-ST83 and 15A-ST63 were the most prevalent penicillin- and meropenem-resistant clones. A transformation study confirmed that penicillin-binding protein (PBP) 2b was the primary meropenem resistance determinant, and PBP1a was essential for high-level resistance. The rate of serotype 15B/C-ST83 increased during the study. All 15B/C-ST83 isolates showed an ermB macrolide resistance genotype. Prediction analysis of recombination sites revealed 12 recombination regions in 15B/C-ST83 compared with the S. pneumoniae Spain23 F-ST81 genome. Pneumococcal clones rapidly recombine to acquire survival advantages and undergo local expansion under the selective pressure exerted by vaccines and antimicrobial drugs. The spread of 15B/C-ST83 is alarming for countries with high antimicrobial pressure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据