期刊
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
卷 167, 期 6, 页码 -出版社
ELECTROCHEMICAL SOC INC
DOI: 10.1149/1945-7111/ab828e
关键词
Progesterone; Gadolinium (III) tungstate nanoparticles; electrochemical sensor; Fast Fourier transformation Square wave voltammetry; Human blood plasma sample
资金
- national elite's foundation of Iran (Tehran, Iran)
- university of Tehran
Gadolinium (III) tungstate nanoparticles (Gd-2(WO4)(3)NPs) modified carbon paste electrode (CPE) was constructed and the electrocatalytic properties of the NPs-modified electrode toward the reduction of progesterone (P4) were analyzed. In relation to the Gd-2(WO4)(3)NPs, wolframite structure, adsorption of P4 on the electrode surface occurred, which was characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Determination of P4 was performed with stripping cyclic voltammetry (CV) and fast Fourier transformation square-wave voltammetry (FFT-SWV) in 0.1 M Britton-Robinson buffer (BRB) solution at pH 11.5. On the other hand, participation of equal numbers of electrons and protons in the reduction reaction of P4 was observed. A reduction peak current at -1.35 V of P4 was obtained, which increased linearly with the P4 concentration in the range of 0.1 to 1.0 mu M (R-2 = 0.972), with higher sensitivity of 485.64 mu A mu M-1 and a limit of detection (LOD) being 50 nM. Common hormones showed no obvious interference with the P4 biosensor's response. Finally, the presented method was able to determine P4 simply and effectively in human blood plasma sample. (c) 2020 The Electrochemical Society (ECS). Published on behalf of ECS by IOP Publishing Limited.
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