期刊
PHARMACEUTICALS
卷 13, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ph13030040
关键词
afamelanotide; bremelanotide; DOTATOC; drugs; Ga-68-DOTATOC; enfortumab vedotin; golodirsen; givosiran; polatuzumab vedotin; oligonucleotides; peptides; pharmaceutical market
资金
- National Research Foundation (NRF) (South Africa)
- University of KwaZulu-Natal (South Africa)
- MINECO (Spain) [RTI2018-093831-B-100]
- Generalitat de Catalunya (Spain) [2017 SGR 1439]
2019 has been an excellent year in terms of peptides and oligonucleotides (TIDES) approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in 2019 in comparison with 2018 (48 vs. 59), the total number of TIDES authorized increased (seven vs. three). Year after year, TIDES are increasingly present in therapy, as imaging agents, theragnostic and constituent moieties of other complex drugs, such as antibody drug conjugates. This means a consolidation of these kinds of drugs in the pharmaceutical arena, paving the way in the coming years for the approval of others for diverse medical indications. Here the TIDES approved in 2019 are analyzed in terms of chemical structure, medical target, mode of action, and adverse effects.
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