期刊
CYTOTHERAPY
卷 17, 期 4, 页码 403-417出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2014.11.011
关键词
acute radiation syndrome; apoptosis; hematopoietic failure; stem cell; superoxide dismutase; umbilical cord mesenchymal stromal cells
类别
资金
- Shenzhen Research and Development grants [ZD201111080130A, CXY201107010176A, JSGG20130917151830203]
- California Institute of Regenerative Medicine (CIRM) [RT2-01942]
- National Institutes of Health [1R43 CA103553-01]
- Department of Defense [W81XWH-04-1-0597]
- Jilin International Collaboration Grant [20120720]
- NSFC [81272294]
- NATIONAL CANCER INSTITUTE [R43CA103553] Funding Source: NIH RePORTER
Background aims. Acute radiation syndrome (ARS) leads to pancytopenia and multi-organ failure. Transplantation of hematopoietic stem cells provides a curative option for radiation-induced aplasia, but this therapy is limited by donor availability. Methods. We examined an alternative therapeutic approach to ARS with the use of human extracellular superoxide dismutase (ECSOD)-modified umbilical cord mesenchymal stromal cells (UCMSCs). This treatment combines the unique regenerative role of UCMSCs with the anti-oxidative activity of ECSOD. Results. We demonstrated that systemically administered ECSOD-UCMSCs are able to protect mice from sub-lethal doses of radiation and improve survival by promoting multilineage hematopoietic recovery. The therapeutic effect of this treatment is related to the decrease in radiation-induced O-2(-) and apoptosis. Conclusions. Our data highlight the clinical potential of this two-pronged approach to the treatment of ARS, thereby serving as a rapid and effective first-line strategy to combat the hematopoietic failure resulting from a radiation accident, nuclear terrorism and other radiologic emergencies.
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