期刊
CHEMICAL SCIENCE
卷 11, 期 14, 页码 3713-3718出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc00532k
关键词
-
资金
- Australian Research Council Discovery Early-Career Researcher Award scheme [DE190100797]
- EU Horizon 2020 Marie Sklodowska-Curie Fellowship [705475]
- DVCR Office at The University of Sydney
- University of Nottingham
- EPSRC [EP/R513052/1]
- Swedish Research Council [VR 4-478/2016]
- Australian Research Council [DE190100797] Funding Source: Australian Research Council
- Marie Curie Actions (MSCA) [705475] Funding Source: Marie Curie Actions (MSCA)
Gating the release of chemical payloads in response to transient signals is an important feature of 'smart' delivery systems. Herein, we report a triazole-based self-immolative linker that can be reversibly paused or slowed and restarted throughout its elimination cascade in response to pH changes in both organic and organic-aqueous solvents. The linker is conveniently prepared using the alkyne-azide cycloaddition reaction, which introduces a 1,4-triazole ring that expresses a pH-sensitive intermediate during its elimination sequence. Using a series of model compounds, we demonstrate that this intermediate can be switched between active and dormant states depending on the presence of acid or base, cleanly gating the release of payload in response to a fluctuating external stimulus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据