4.0 Review

Centromeric Non-Coding RNAs: Conservation and Diversity in Function

期刊

NON-CODING RNA
卷 6, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/ncrna6010004

关键词

centromere; chromosome segregation; RNP

资金

  1. Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [26870442, 24770168, 23112716]
  2. Shinnihon Foundation of Advanced Medical Treatment Research
  3. Astellas Foundation for Research on Metabolic Disorders
  4. Grants-in-Aid for Scientific Research [24770168, 26870442] Funding Source: KAKEN

向作者/读者索取更多资源

Chromosome segregation is strictly regulated for the proper distribution of genetic material to daughter cells. During this process, mitotic chromosomes are pulled to both poles by bundles of microtubules attached to kinetochores that are assembled on the chromosomes. Centromeres are specific regions where kinetochores assemble. Although these regions were previously considered to be silent, some experimental studies have demonstrated that transcription occurs in these regions to generate non-coding RNAs (ncRNAs). These centromeric ncRNAs (cenRNAs) are involved in centromere functions. Here, we describe the currently available information on the functions of cenRNAs in several species.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.0
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据