期刊
JOURNAL OF ANTIBIOTICS
卷 70, 期 10, 页码 1029-1032出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2017.89
关键词
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资金
- National Natural Science Foundation of China [81422045, U1405223, 81661138005]
- Fundamental Research Funds for the Central Universities of China [20720160064, 20720160031]
- Xiamen Southern Oceanographic Center [14GYY002NF02]
Four new 12,8-Eudesmanolides (1-4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1-15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC50 values of 8.4 and 28.5 pm, respectively. Additionally, compound 1 also showed moderate antimicrobial activity.
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