期刊
ARTIFICIAL LIFE AND ROBOTICS
卷 25, 期 2, 页码 199-203出版社
SPRINGER
DOI: 10.1007/s10015-020-00605-7
关键词
Vascular-like structure; Support hydrogel; Bioprinting; Cell sheet
类别
资金
- Japan Society for the Promotion of Science [18K18838]
- Japan Science and Technology Agency [JPMJMI18CD]
- Grants-in-Aid for Scientific Research [18K18838] Funding Source: KAKEN
Vascular structures are essential for the survival of thick artificial three-dimensional (3D) tissues. However, it is difficult to create high-cell-density artificial tissue with vascular structures of a few hundred micrometers in diameter. Bioprinting technology can create artificial 3D tissues with vascular structures of a few hundred micrometers in diameter, but the cell density of bio-printed artificial 3D tissues is low. On the other hand, cell sheet technology can create high-cell-density artificial 3D tissues by stacking, but it is not possible to set small vascular structures at any place. In this study, we successfully demonstrated high-cell-density artificial 3D tissues with vascular-like structures by stacking cell sheets combined with bioprinting technology.
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