期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 26, 页码 3801-3804出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00293c
关键词
-
资金
- 100 Young Talents Programme of Guangdong University of Technology [220413292]
A new general de novo synthesis of pharmaceutically important alpha-aryl beta-perfluoroalkyl ketones has been disclosed. Compared with trifluoromethylation-initiated radical 1,2-aryl migration of alpha,alpha-diaryl allylic alcohols, this protocol employs a new strategy of biomimetic carbene catalysis to assemble alkene, aldehyde and perfluoroalkyl reagents, providing access to products with excellent flexibility of the aryl unit and perfluoroalkyl group. This method also demonstrates excellent functional group compatibility, including some Grignard reagent sensitive groups.
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