期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 60, 期 3, 页码 1025-1034出版社
IOS PRESS
DOI: 10.3233/JAD-170564
关键词
Alzheimer's disease; amyloid-beta (1-42); cerebrospinal fluid; mild cognitive impairment; olfaction
资金
- European Commission as part of 6th Framework Programme [37670]
Background: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). Objective: To investigate the association between odor identification and amyloid-beta 1-42 (A beta(42)) and total tau (t-tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF A beta(42) and t-tau and apolipoprotein E (APOE) genotype. Methods: We included 160 individuals (40 with normal cognition, 45 with mild cognitive impairment (MCI), 42 with AD-type dementia, and 26 individuals with non-AD dementia) from the EDAR study. Individuals were recruited from six memory clinics across Europe. Odor identification was tested with the brief University of Pennsylvania Smell Identification Test. CSF A beta(42) and t-tau were assessed with INNO-BIA AlzBio3 Luminex assay. Neuropsychological assessment included tests for verbal memory, verbal fluency, attention, executive function, and visuoconstruction. Follow-up was performed within 3 years after baseline. Results: Lower odor identification scores correlated with increased CSF t-tau concentrations and with lower scores on all cognitive measures at baseline independent of diagnostic group. Lower odor identification scores predicted decline on the MMSE in the total group, and decline on wordlist learning and delayed recall in APOE epsilon 4 carriers and in individuals with abnormal A beta(42). Conclusion: Odor identification impairment may be an indicator of neuronal injury rather than amyloid pathology.
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