期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 57, 期 4, 页码 1157-1170出版社
IOS PRESS
DOI: 10.3233/JAD-161111
关键词
Alzheimer's disease; amyloid-beta; apoptosis; endoplasmic reticulum stress; neurofibrillary tangles
Alzheimer's disease (AD) is a dementia disease with neuronal loss and synaptic impairment. This impairment is caused, at least partly, by the generation of two main AD hallmarks, namely the hyperphosphorylated tau protein comprising neurofibrillary tangles and senile plaques containing amyloid-beta (A beta) peptides. The amyloid-beta protein precursor (A beta PP) and glycogen synthase kinase-3 beta (GSK3 beta) are two main proteins associated with AD and are closely correlated with these hallmarks. Recently, both of the proteins were reported to be modulated by endoplasmic reticulum stress (ERS) and are involved in the pathogenesis of AD. The mechanism of ERS plus the modulation of A beta PP processing and GSK3 beta activity by ERS in AD are summarized and explored in this review.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据