期刊
FEMS MICROBIOLOGY LETTERS
卷 367, 期 10, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnaa080
关键词
social cheating; Pseudomonas aeruginosa; public goods; quorum sensing; policing
类别
资金
- CONACYT [A1-S-8530, CB 252269]
- PAPITT UNAM [IN214218, IN201819]
Pseudomonas aeruginosa is one of the main models to study social behaviors in bacteria since it synthesizes several exoproducts, including exoproteases and siderophores and release them to the environment. Exoproteases and siderophores are public goods that can be utilized by the individuals that produce them but also by non-producers, that are considered social cheaters. Molecularly exoprotease cheaters are mutants in regulatory genes such as lasR, and are commonly isolated from chronic infections and selected in the laboratory upon serial cultivation in media with protein as a sole carbon source. Despite that the production of exoproteases is exploitable, cooperators have also ways to restrict the growth and selection of social cheaters, for instance by producing toxic metabolites like pyocyanin. In this work, using bacterial competitions, serial cultivation and growth assays, we demonstrated that rhamnolipids which production is regulated by quorum sensing, selectively affect the growth of lasR mutants and are able to restrict social cheating, hence contributing to the maintenance of cooperation in Pseudomonas aeruginosa populations.
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