期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 61, 期 1, 页码 17-28出版社
IOS PRESS
DOI: 10.3233/JAD-170654
关键词
Concussion; neurodegenerative; neuropathology; tau
资金
- National Institutes of Health [G12-MD007591, U01 NS086625, P50 AG05136]
- Nancy and Buster Alvord Endowment
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U01NS086625] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P50AG005136] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [G12MD007591] Funding Source: NIH RePORTER
There is tremendous recent interest in chronic traumatic encephalopathy (CTE) in former collision sport athletes, civilians, and military veterans. This critical review places important recent research results into a historical context. In 2015, preliminary consensus criteria were developed for defining the neuropathology of CTE, which substantially narrowed the pathology previously reported to be characteristic. There are no agreed upon clinical criteria for diagnosis, although sets of criteria have been proposed for research purposes. A prevailing theory is that CTE is an inexorably progressive neurodegenerative disease within the molecular classification of the tauopathies. However, historical and recent evidence suggests that CTE, as it is presented in the literature, might not be pathologically or clinically progressive in a substantial percentage of people. At present, it is not known whether the emergence, course, or severity of clinical symptoms can be predicted by specific combinations of neuropathologies, thresholds for accumulation of pathology, or regional distributions of pathologies. More research is needed to determine the extent to which the neuropathology ascribed to long-term effects of neurotrauma is static, progressive, or both. Disambiguating the pathology from the broad array of clinical features that have been reported in recent studies might facilitate and accelerate research-and improve understanding of CTE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据