期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 61, 期 2, 页码 571-580出版社
IOS PRESS
DOI: 10.3233/JAD-170736
关键词
Acrolein; acrolein-conjugated protein (Acr-PC); Alzheimer's disease; 3-HPMA
资金
- Ministry of Science and Technology, Taiwan [104-2320-B-010-040-MY3, 104-2314-B-075-005-MY2, 104-2314-B-010-071-MY3]
- Academia Sinica of Taiwan [Taiwan Biobank: Biosignature Study of Alzheimer Disease]
- Taipei Veterans General Hospital [V106C-126]
Alzheimer's disease (AD) is a detrimental neurodegenerative disease, and early diagnosis appears to be the key to successful treatment. Acrolein, a byproduct of lipid peroxidation, has been shown to contribute to the pathological process of AD. This study recruited 118 elderly subjects consisting of 58 non-demented control subjects and 62 AD patients. We analyzed the acrolein-related metabolites in the plasma, cerebrospinal fluid (CSF), and urine of all subjects. We found that the levels of acrolein-conjugated protein (Acr-PC) in the plasma (p = 0.00012) and CSF (p = 0.00161) of AD patients were significantly higher than those of control subjects, whereas the levels of a urinary acrolein metabolite, 3-hydroxypropyl mercapturic acid (3-HPMA), were markedly decreased (p = 0.00882) in AD patients. These data suggest that deregulated acrolein metabolism may be correlated with neuronal damage in AD patients, which might provide further insights into the disease progression and early diagnosis of AD.
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