期刊
ACS APPLIED NANO MATERIALS
卷 3, 期 3, 页码 2517-2526出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.9b02606
关键词
photothermal therapy; NaNdF4; temperature feedback; light-to-heat conversion efficiency; pulsed laser ablation
资金
- Fundamental Research funds for the Central Universities [3072019CF2516]
- Natural Science Foundation of Heilongjiang Province [LC2018026]
- 111 project [B13015]
Photothermal therapy (PTT) has been widely used for the treatment of various medical conditions due to their noninvasive and cost-effective advantages. However, the light absorption and scattering of the biosystem limit the deep tissue applications of conventional PTT probes. In this paper, we proposed the sub-10 nm NaNdF4 nanocrystals with both incident and emission wavelengths located at the optical window. Under 800 nm laser excitation, the maximum light-to-heat conversion efficiency of these ultrasmall photothermal agents is evaluated to be 85%. In addition, the conversion efficiency can be further adjusted through varying the doping concentration, changing the probe size, and coating the inert shell. Meanwhile, temperature feedback on the basis of the Nd3+ luminescence signal validates the precise temperature manipulating inside the biological tissue, evidencing the feasibility of the proposed probes for PTT treatment. Beneficial 1.5 cm from the efficient photothermal conversion and low energy loss of excitation/emission photons in organic tissue, the effective treatment depth of the nanoprobes goes to 6 mm with the actual laser power density only similar to 0.2 W/cm(2). Finally, based on the rapid heating response of the formed nanoprobes, fast ablation treatment of a pork tissue is achieved using pulsed laser.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据