期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 16, 期 11, 页码 1929-1940出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.45231
关键词
m(6)A modification; methylation; RNA; function
资金
- National Natural Science Foundation of China [8187208, 81572349]
- Jiangsu Provincial Medical Talent [ZDRCA 2016055]
- Science and Technology Department of Jiangsu Province [BK20181148]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 333 high-level talents of Jiangsu Province [BRA2019083]
N6-methyladenosine (m(6)A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by m(6)A binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers). Accumulating evidence shows that m(6)A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses. In this review, we mainly summarize and discuss the functional relevance and importance of m(6)A modification in cellular processes.
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