期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 16, 期 11, 页码 1811-1820出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.41637
关键词
exosome; osteoarthritis; cartilage; exosomal RNA; stem cells; cellular and exosomal therapies
资金
- National Key R&D Program of China [2019YFA0111900]
- Key Scientific and Technological Innovation Group of Zhejiang Province [2013TD11, LY17H060003]
- NSFC [81201395]
- Dr. Li Dak Sum & Yip Yio Chin Development Fund for Regenerative Medicine
Articular cartilage injury is a common clinical problem, which can lead to joint dysfunction, significant pain, and secondary osteoarthritis (OA) in which major surgical procedures are mandatory for treatment. Exosomes, as endosome-derived membrane-bound vesicles, participating in intercellular communications in both physiological and pathophysiological conditions, have been attached great importance in many fields. Recently, the significance of exosomes in the development of OA has been gradually concerned, while the therapeutic value of exosomes in cartilage repair and OA treatment has also been gradually revealed. The functional difference of different types and derivations of exosomes are determined by their specific contents. Herein, we provide comprehensive understanding on exosome and OA, including how exosomes participating in OA, the therapeutic value of exosomes for cartilage injury/OA, and related bioengineering strategies for future therapeutic design.
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