期刊
FOOD & FUNCTION
卷 11, 期 3, 页码 2427-2438出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo02927c
关键词
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资金
- National Natural Science Foundation of China [81573580]
- Key Laboratory of Polysaccharide Bioactivity Evaluation of TCM of Liaoning Province, Key Techniques Study of Consistency Evaluation of Drug Quality and Therapeutic Effect [18-400-4-08]
- Liaoning Distinguished Professor Project for Ying Jia
- Doctoral Scientific Research Foundation of Liaoning Province [2019-BS-233]
- Precise Screening Technology of Antidepressant active Components in Traditional Chinese Medicine [2017LZD01]
Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens elderly health. Schisandrin (SCH) and nootkatone (NKT) are two core components derived from Alpinia oxyphylla-Schisandra chinensis herb pair (ASHP), a traditional Chinese medicine formulation. Previous studies demonstrated that the combination of NKT and SCH exerted a neuroprotective effect in AD mouse models. The present study was undertaken to investigate whether there was a synergistic effect between NKT and SCH and the possible mechanism in A beta(1-42) induced PC12 cells. SCH (50 mu M) and NKT (10 mu M) had the most notable inhibitory effect on the level of A beta secreted by cells. Treatment with NKT + SCH activated the PI3K/AKT/Gsk-3 beta/mTOR pathway. Inflammation related proteins such as NF-kappa B, IKK, IL-1 beta, IL-6 and TNF-alpha were decreased. The levels of cleaved-Caspase3 and LC3-II were reduced, indicating that apoptosis and autophagy were inhibited. These results revealed that NKT + SCH exerted a neuroprotective effect via the PI3K/AKT pathway, inhibiting inflammation, apoptosis and autophagy.
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