期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 15, 页码 3050-3057出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00176g
关键词
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资金
- CSIR-CSMCRI [164/2019]
- Department of Science and Technology, Government of India [EMR/2016/004747]
Magnetic proline-based surface-active ionic liquid ([ProC(10)][FeCl3Br]) have been synthesized and investigated for their application in hydrophobic drug delivery. Hydrophobic drugs lead to poor absorptivity, drug aggregation, and high local toxicity. Herein, the vesicular structures formed from [ProC(10)][FeCl3Br] have been used as drug delivery reactors. The self-assembly behavior of [ProC(10)][FeCl3Br] in aqueous medium has been investigated using tensiometry, fluorescence, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The physicochemical interactions of [ProC(10)][FeCl3Br] with animal DNA have been studied using circular dichroism (CD), fluorescence, zeta potential, and gel electrophoresis to confirm its bio-friendly nature. The engendered vesicles prepared from [ProC(10)][FeCl3Br] have been investigated for the in vitro drug delivery of guest molecule pyrene as a hydrophobic model drug and ciprofloxacin as a hydrophobic antibiotic drug. The drug loading capacity and spontaneous kinetic release of the drug have been studied using various theoretical mathematical drug release models.
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