期刊
GENOME BIOLOGY
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13059-020-02008-0
关键词
Chromatin accessibility; Single cell; Genomics; Bioinformatics
资金
- National Institutes of Health of United States of America [HD089245, CA226187, CA233285]
- Leona M. and Harry B Helmsley Charitable Trust [2008-04062]
- Alex's Lemonade Stand Foundation
Single-cell chromatin accessibility sequencing has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. However, there is a lack of open-source software for comprehensive processing, analysis, and visualization of such data generated using all existing experimental protocols. Here, we present scATAC-pro for quality assessment, analysis, and visualization of single-cell chromatin accessibility sequencing data. scATAC-pro computes a range of quality control metrics for several key steps of experimental protocols, with a flexible choice of methods. It generates summary reports for both quality assessment and downstream analysis. scATAC-pro is available at .
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