期刊
BIOMATERIALS SCIENCE
卷 8, 期 6, 页码 1575-1579出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm02088h
关键词
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资金
- National Key Research and Development Program of China [2018YFA0107301, 2017YFA0205201]
- National Natural Science Foundation of China [81422023, 81603015, U1505221, U1705281, 81371596]
- Fundamental Research Funds for the Central Universities [20720160065, 20720150141]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
Perihilar cholangiocarcinoma (PHCC) presents a formidable challenge due to its occult anatomic location, aggressive growth, insensitivity to conventional chemotherapy, and poor prognosis. Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. The A-NVs@ICG were prepared and exhibited satisfactory targeting effects in HER2-overexpressing PHCC cells. In vivo fluorescence and photoacoustic imaging demonstrated that A-NVs@ICG promoted the accumulation of ICG in PHCC tissue, leading to enhanced tumor regression and improved anti-cancer effects when combined with photoirradiation. Therefore, bio-engineered A-NVs@ICG represent a promising nanotheranostic agent for PHCC with potential for clinical translation.
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