期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 139, 期 6, 页码 1736-1751出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2017.04.005
关键词
Asthma; tight junction; innate immunity; cytokine; homeostasis
资金
- Medical Research Council (MRC [UK])
- National Centre for Reduction Refinement and Replacement of Animals in Research (NC3Rs [UK])
- Asthma UK
- Asthma Allergy and Inflammation Research Charity (AAIR)
- National Institute for Health Research (NIHR [UK])
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Biotechnology and Biological Sciences Research Council [BB/P011365/1] Funding Source: researchfish
- Medical Research Council [G0800766, G0900453] Funding Source: researchfish
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [G1001598/1] Funding Source: researchfish
- BBSRC [BB/P011365/1] Funding Source: UKRI
- MRC [G0900453] Funding Source: UKRI
The bronchial epithelium is continuously exposed to a multitude of noxious challenges in inhaled air. Cellular contact with most damaging agents is reduced by the action of the mucociliary apparatus and by formation of a physical barrier that controls passage of ions and macromolecules. In conjunction with these defensive barrier functions, immunomodulatory cross-talk between the bronchial epithelium and tissue-resident immune cells controls the tissue microenvironment and barrier homeostasis. This is achieved by expression of an array of sensors that detect a wide variety of viral, bacterial, and nonmicrobial (toxins and irritants) agents, resulting in production of many different soluble and cell-surface molecules that signal to cells of the immune system. The ability of the bronchial epithelium to control the balance of inhibitory and activating signals is essential for orchestrating appropriate inflammatory and immune responses and for temporally modulating these responses to limit tissue injury and control the resolution of inflammation during tissue repair. In asthmatic patients abnormalities in many aspects of epithelial barrier function have been identified. We postulate that such abnormalities play a causal role in immune dysregulation in the airways by translating gene-environment interactions that underpin disease pathogenesis and exacerbation.
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